So although I am hesitant to predict when the age of intelligent machines will be a reality, I think that if enough people apply themselves to solving this problem today, we may be able to create useful prototypes and cortical simulations within just a few years. Within ten years, I hope, intelligent machines will be one of the hottest areas of technology and science. I am reluctant to be more specific than this, because I know how easy it is to underestimate the time it takes to make something important happen. So why am I so optimistic about the speed of progress in understanding the brain and building intelligent machines? My confidence stems mostly from the long time I have already spent working on the problem of intelligence. When I first fell in love with brains, in 1979, I felt solving the puzzle of intelligence was something that could be achieved in my lifetime. Over the years, I have carefully observed the decline of AI, the rise and fall of neural networks, and the Decade of the Brain in the 1990s. I have seen how attitudes toward theoretical biology, and theoretical neuroscience in particular, have evolved. I have seen how the ideas of prediction, hierarchical representation, and time have crept into the language of neuroscience. I have seen the progress in my own understanding and that of my colleagues. I became excited about the role of prediction eighteen years ago and have in some ways been testing it ever since. Because I have been immersed in the neuroscience and computer fields for over two decades, perhaps my brain has built a high-level model of how technological and scientific change occurs, and that model predicts rapid progress. Now is the turning point.